In this supplement spotlight, you’ll discover the powerful role folate plays in hormone balance, ovulation, mood, and pregnancy, and why not all forms of folate are created equal. From supporting methylation and reducing inflammation to improving egg quality and fetal development, folate is one of the most important nutrients for women with PCOS. But here’s the kicker: many common supplements contain folic acid, a form your body may not be able to use, especially if you have the common MTHFR gene mutation.
Episode #176: Folate & PCOS: Not All Forms Are Equal
Episode #176: Folate & PCOS: Not All Forms Are Equal
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What you’ll learn in this episode:
In this supplement spotlight episode of the PCOS Repair Podcast, you will learn why folate is one of the most essential nutrients for women with PCOS—especially when it comes to hormone balance, mood support, and fertility. Whether you’re preparing for pregnancy, currently expecting, or simply aiming to improve your hormone health, this episode breaks down everything you need to know about folate, including how it works in the body and why not all forms of folate are beneficial.
Folate’s Role in Fertility, Hormone Balance, and Methylation
You will discover how folate, also known as vitamin B9, supports healthy ovulation, egg quality, and early fetal development, making it a critical nutrient before and during pregnancy. Beyond fertility, folate plays a key role in DNA synthesis, cell repair, red blood cell production, and hormone metabolism. You’ll also learn how it helps reduce elevated homocysteine levels, which are often linked to inflammation and miscarriage risk in women with PCOS.
Why the Form of Folate Matters: Folic Acid vs. L-Methylfolate
In this episode, you’ll explore the common MTHFR gene mutation that affects up to 60% of women and learn why folic acid, the synthetic form found in most prenatal vitamins, may not be effective for many individuals. You’ll discover why L-methylfolate or 5-MTHF is the preferred and most bioavailable form, especially for those with MTHFR mutations, and how unmetabolized folic acid can actually increase hormone imbalances, fatigue, and inflammation.
How to Choose a Quality Folate Supplement
You’ll gain practical guidance on how to read supplement labels, which forms of folate to look for, and what to avoid. This episode breaks down recommended dosages and explains why methylated B-complex or prenatal formulas that include B6, B12, and L-methylfolate are often the most effective. You’ll also get tips on how to identify reputable brands and ensure your supplements are third-party tested for safety and effectiveness.
Final Thoughts on Folate and PCOS
This episode wraps up by emphasizing that folate is not just a fertility supplement, it’s a foundational nutrient that supports many aspects of PCOS healing. You’ll walk away with a clear understanding of why folate matters, how to choose the right form and dose, and how to integrate it into your holistic hormone health plan. Be sure to check out the free PCOS Supplement Guide linked in the show notes and consult your healthcare provider for personalized support.
Let’s Continue The Conversation
Do you have questions about this episode or other questions about PCOS? I would love to connect and chat on a more personal level over on Instagram. My DMs are my favorite place to chat more.
So go visit me on IG @nourishedtohealthy.com
Let’s Continue The Conversation
Do you have questions about this episode or other questions about PCOS? I would love to connect and chat on a more personal level over on Instagram. My DMs are my favorite place to chat more.
So go visit me on IG @nourishedtohealthy.com
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Read The Full Episode Transcript Here
Hi, and welcome back to the PCOS Repair Podcast. This episode is a supplement highlight. Today, we’re going to be talking about a supplement that gets a lot of interest when we’re thinking about fertility and pregnancy, and that is folate.
Whether you are currently trying to conceive, currently pregnant, thinking about which prenatal to take, or just want to support your hormone health, understanding folate is really essential. This is one that even comes into play with a lot of different mood disorders and our mental health. So it’s really not just fertility-related. It’s very important when it comes to fertility because it assists in your baby’s development of the spinal cord and nervous system while in utero. This one’s a very important one.
One of the reasons why I think this episode is so important—and why this supplement is so important to highlight—is that we talk a lot about which brand you take and all of that. Not all supplements are created equal or reputable. But when it comes to folate, this is very, very important. Not all folate is created equal, not all forms make a difference, and some can even be problematic.
So that’s what we’re going to get into in today’s episode. Let’s dive in.
Why Folate Matters
So first of all, why does folate matter? Basically, folate is a B vitamin—specifically vitamin B9—that’s involved in DNA synthesis, cell repair, and red blood cell production. For women with PCOS, it’s especially important for a few key reasons.
- Fertility and Pregnancy Support:
Folate is essential for early pregnancy development. It reduces the risk of neural tube defects—issues that can affect the spinal cord and brain. But it even helps prior to getting pregnant. Folate is essential for ovulation and egg quality, and of course, in early pregnancy. - Hormone Metabolism:
Folate supports methylation, which helps the body process and clear out excess hormones and toxins. One of the reasons many women become estrogen dominant is due to a buildup of estrogen. We need to not only produce hormones but also clear them out so that fresh hormones can be released without an excess. - Homocysteine Levels:
High homocysteine—often seen in women with PCOS—is linked to inflammation, cardiovascular issues, and increased miscarriage risk. Folate helps reduce these levels.
The MTHFR Mutation and Folic Acid vs. Folate
Many women with PCOS also have a genetic mutation called MTHFR. This makes it very difficult to convert folic acid—the synthetic version of folate—into its active, usable form.
Folic Acid vs. Folate:
Folic acid is the synthetic version commonly found in supplements and fortified foods. It’s stable and easy to manufacture but not everyone can use it efficiently. Most prenatal vitamins contain folic acid, assuming it will protect against neural tube defects and provide B9. However, research is finding that up to 60% of people have a variation in their MTHFR gene that slows or blocks the conversion of folic acid into its active form: L-methylfolate.
So while folic acid sounds like it should be helpful, for a large portion of the population, it’s not. In fact, unmetabolized folic acid can build up in the body, potentially worsening hormone symptoms, causing fatigue, increasing inflammation, and even increasing miscarriage risk according to some studies.
And that’s why today’s supplement spotlight is so important.
What to Look For in a Folate Supplement
If you’re taking a prenatal or multivitamin that contains folic acid, it’s time to switch that out. You can get my full PCOS supplement guide—I’ll link to it in the show notes—and see which brands I recommend. Fullscript is a great resource that screens their products for quality, so when you order through that dispensary, you’re already filtering for reputable brands that meet rigorous testing standards.
What to Choose Instead:
Look for the active form: L-methylfolate or 5-MTHF. This form bypasses the MTHFR step, so even if you have a genetic mutation, your body still receives the usable version of this critical nutrient without the risk of synthetic buildup.
Choosing the Right Supplement
First, make sure your supplement lists the active form: L-methylfolate (most commonly seen on labels) or 5-MTHF. Avoid supplements that just list folic acid without specifying if it’s the active form, because that usually means it’s the synthetic version.
Dosage:
Typically, you’ll see 400–800 micrograms (mcg) for general support. For those trying to conceive or who know they have an MTHFR mutation, doses around 1–2 milligrams (mg) are common. Always consult your healthcare provider, especially for dosing.
Combination Formulas:
Folate works well with other B vitamins like B6 and B12. A quality methylated B-complex or prenatal with active forms of all three can be a very effective way to supplement. Again, avoid synthetic blends. Many drugstore prenatals contain low-quality ingredients. Look for brands that are transparent, third-party tested, and use bioavailable active forms.
Third-party testing means supplements are tested by independent labs that don’t have a financial stake in the brand. This ensures the product has been evaluated for purity and quality. Not all supplements go through this, which is why Fullscript is such a helpful resource.
Folate in Food
Since folate is a vitamin, you can also get it from food. Leafy greens like spinach, kale, and romaine lettuce are great sources. Asparagus, avocados, beets, lentils, and black beans also contain natural folate—not folic acid—so they support your levels in a safe and natural way.
However, food sources alone often aren’t enough to meet the needs of women with PCOS—especially those trying to conceive. Due to the high risk associated with early pregnancy defects, it’s highly recommended to supplement in addition to getting folate from food.
Still, I love to know which foods provide certain nutrients so I can create a more well-rounded nutritional foundation. Supplements give us a concentrated dose, but our bodies don’t always absorb every bit. Food helps round out that support.
So again: spinach, kale, romaine, asparagus, avocado, beets, lentils, and black beans—these are all great folate-rich foods to include.
Final Thoughts
So there you have it, my friend. This is such an important supplement, and I hope today’s episode has helped shed light on why it matters so much.
As always, supplementation is just one piece of the holistic PCOS puzzle. When choosing supplements, go with reputable brands. I encourage you to check out my free PCOS Supplement Guide—linked below in the show notes. And always talk to your healthcare professional to make sure what you’re taking is right for your specific needs, especially when it comes to dosing.
If you enjoyed today’s episode and found it helpful, be sure to hit that subscribe button so you’re notified each and every week when a new episode becomes available.
Until next time, bye for now.
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About Show
Welcome to The PCOS Repair Podcast!
I’m Ashlene Korcek, and each week I’ll be sharing the latest findings on PCOS and how to make practical health changes to your lifestyle to repair your PCOS at the root cause.
If you’re struggling with PCOS, know that you’re not alone. In fact, it’s estimated that one in ten women have PCOS. But the good news is that there is a lot we can do to manage our symptoms and live healthy, happy lives.
So whether you’re looking for tips on nutrition, exercise, supplements, or mental health, you’ll find it all here on The PCOS Repair Podcast. Ready to get started? Hit subscribe now









